|
|
progesterone + O2 + reduced_acceptor <=> Testosterone_acetate + H2O + acceptor
|
1.14.99.4
progesterone monooxygenase
|
–
|
|
|
BRENDA:
BR40382
KEGG:
R02212
MetaCyc:
PROGESTERONE-MONOOXYGENASE-RXN
|
|
|
|
progesterone + O2 + reduced_acceptor <=> 11alpha-hydroxyprogesterone + H2O + acceptor
|
1.14.99.14
progesterone 11alpha-monooxygenase
|
–
|
K
|
|
BRENDA:
BR40393;
BS415731
KEGG:
R02214
MetaCyc:
PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
|
|
|
|
progesterone + NADPH + H+ + O2 <=> Testosterone_acetate + NADP+ + H2O
|
1.14.13.54
ketosteroid monooxygenase
1.14.99.4
progesterone monooxygenase
|
–
–
|
|
|
BRENDA:
BR49815
KEGG:
R02210
MetaCyc:
RXN-7817
SABIO-RK:
2182
|
|
|
|
5-Pregnene-3,20-dione <=> progesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
M
|
|
BRENDA:
BS1077
MetaCyc:
RXN66-354
|
|
|
|
5alpha-dihydroprogesterone + NADP+ <=> progesterone + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
MK
|
|
BRENDA:
BS258427
KEGG:
R02208
MetaCyc:
PROGESTERONE-5-ALPHA-REDUCTASE-RXN
SABIO-RK:
2180
|
|
|
|
pregnenolone + NAD+ <=> progesterone + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
BK
|
|
BRENDA:
BS383305
KEGG:
R02216
MetaCyc:
RXN-9722
SABIO-RK:
2188
|
|
|
|
5beta-pregnane-3,20-dione + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
1.3.1.M16
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
–
–
–
–
|
MK
|
|
BRENDA:
BS389592
KEGG:
R02219
MetaCyc:
RXN-9726
SABIO-RK:
2191
|
|
|
|
progesterone + NADPH <=> 20alpha-hydroxyprogesterone + NADP+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.189
prostaglandin-E2 9-reductase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS187276;
BS188322
KEGG:
R02209
SABIO-RK:
2181
|
|
|
|
progesterone + NADH <=> 20alpha-hydroxyprogesterone + NAD+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS187276-a;
BS188322-a
KEGG:
R02207
SABIO-RK:
2179
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 17alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
K
|
|
BRENDA:
BS258003
KEGG:
R02211
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 11-deoxycorticosterone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
BRENDA:
BS427511
KEGG:
R02213
|
|
|
|
progesterone + [2Fe-2S]-center + O2 + H+ <=> 15beta-hydroxy-progesterone + [2Fe-2S]-center + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
KEGG:
R09587
MetaCyc:
RXN-11240
|
|
|
|
progesterone + NADPH + O2 <=> 11-deoxycorticosterone + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
1.14.14.16
steroid 21-monooxygenase
|
–
–
|
|
|
BRENDA:
BS186802
SABIO-RK:
7228
|
|
|
|
5beta-pregnane-3,20-dione + acceptor <=> progesterone + reduced_acceptor
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
K
|
|
KEGG:
R02215
|
|
|
|
progesterone + 2 reduced_ferredoxin + O2 + 2 H+ <=> 11beta-hydroxyprogesterone + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
|
KEGG:
R02218
|
|
|
|
progesterone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 17alpha-hydroxyprogesterone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-355
|
|
|
|
progesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycorticosterone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-358
|
|
|
|
progesterone + [reduced_NADPH-P450_reductase] + O2 <=> 11-deoxycorticosterone + [oxidized_NADPH-P450_reductase] + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS427514
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 16alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
–
|
|
|
BRENDA:
BS428887
|
|
|
|
progesterone + reduced_flavodoxin + O2 <=> 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + flavin + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS427512
|
|
|
|
progesterone + 2,6-dichlorophenolindophenol <=> 1,4-Pregnene-3,20_dione + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS398163
|
|
|
|
progesterone + 2,6-dichlorophenolindophenol <=> pregna-1,4-diene + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS441879
|
|
|
|
5beta-pregnane-3,20-dione + menadione <=> progesterone + menadiol
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
|
BRENDA:
BS258883
|
|
|
|
5beta-pregnane-3,20-dione + phenazine_methosulfate <=> progesterone + phenazine_methosulfate
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
|
BRENDA:
BS258884
|
|
|
|
progesterone + reduced_ferredoxin + O2 + H+ <=> 15beta-hydroxy-progesterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BR49149
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-progesterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS406466
|
|
|
|
progesterone + reduced_megaredoxin + O2 <=> 15beta-hydroxy-progesterone + oxidized_megaredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS406469
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 11-deoxycorticosterone + A + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS406463
|
|
|
|
2 progesterone + 2 reduced_acceptor + 2 O2 <=> 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + 2 A + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS394960
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 17alpha-hydroxyprogesterone + A + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS394961
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 9alpha-hydroxyprogesterone + A + H2O
|
1.14.99.24
steroid 9alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS394962
|
|
|
|
progesterone + NADH + O2 <=> 11-deoxycorticosterone + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186795
|
|
|
|
4-pregnen-3alpha-ol-2-one + NAD+ <=> progesterone + NADH + H+
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS438872
|
|
|
|
progesterone + NADH <=> 5beta-pregnane-3,20-dione + NAD+
|
1.3.99.6
3-oxo-5beta-steroid 4-dehydrogenase
|
–
|
|
|
BRENDA:
BS258873
|
|
|
|
20alpha-hydroxyprogesterone + NADH + H+ <=> progesterone + NAD+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
–
|
|
|
BRENDA:
BS424504-a
|
|
|
|
pregnenolone + NADH + H+ <=> progesterone + NAD+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS426945
|
|
|
|
pregnenolone + NAD+ <=> 5-Pregnene-3,20-dione + progesterone + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS398144
|
|
|
|
progesterone + NADH <=> 3alpha-hydroxy-4-pregnen-20-one + NAD+
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
–
–
|
|
|
BRENDA:
BS187028-a
|
|
|
|
5-pregnen-3beta-ol-2-one + NAD+ <=> progesterone + NADH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS370818
|
|
|
|
4-pregnen-20alpha-ol-3-one + NAD+ <=> progesterone + NADH + H+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS372103-a
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 11beta-hydroxyprogesterone + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS426947
|
|
|
|
progesterone + reduced_adrenodoxin + O2 <=> 15beta-hydroxy-progesterone + 11alpha-hydroxyprogesterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443861
|
|
|
|
pregnenolone <=> progesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS428886
|
|
|
|
progesterone + 2 reduced_acceptor + 2 O2 <=> 4-androstene-3,17-dione + acetate + 2 A + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS407298
|
|
|
|
progesterone + NADP+ <=> 20beta-hydroxyprogesterone + NADPH + H+
|
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS437833
|
|
|
|
20alpha-hydroxyprogesterone + NADPH + H+ <=> progesterone + NADP+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
–
|
|
|
BRENDA:
BS424504
|
|
|
|
pregnenolone + NADPH <=> progesterone + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS389583
|
|
|
|
progesterone + NADPH + O2 <=> 16alpha-hydroxyprogesterone + 2beta,16alpha-dihydroxyprogesterone + NADP+ + H2O
|
1.14.99.4
progesterone monooxygenase
|
–
|
|
|
BRENDA:
BS287904
|
|
|
|
progesterone + NADPH <=> allopregnanolone + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS398165
|
|
|
|
progesterone + NADPH + O2 <=> 11alpha-hydroxyprogesterone + NADP+ + H2O
|
1.14.99.14
progesterone 11alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS287964
|
|
|
|
pregnenolone + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS406431
|
|
|
|
progesterone + 2 NADPH + 2 H+ + 2 O2 <=> 4-androstene-3,17-dione + acetate + 2 NADP+ + 2 H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS407302
|
|
|
|
progesterone + NADPH <=> pregnan-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS258423
|
|
|
|
progesterone + NADPH <=> 3beta-hydroxy-4-pregnen-20-one + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS257053
|
|
|
|
progesterone + NADPH <=> 3alpha-hydroxy-4-pregnen-20-one + NADP+
|
1.1.1.112
indanol dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
|
–
–
|
|
|
BRENDA:
BS187028
|
|
|
|
3alpha-hydroxypregn-4-en-20-one + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
|
BRENDA:
BS370798
|
|
|
|
4-pregnen-20alpha-ol-3-one + NADP+ <=> progesterone + NADPH + H+
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS372103
|
|
|
|
progesterone + NADPH <=> 5beta-pregnan-3,11,20-trione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS398166
|
|
|
|
progesterone + reduced_acceptor + O2 <=> 17alpha-hydroxyprogesterone + acceptor + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
–
|
|
|
BRENDA:
BS415732
|
|
|
|
progesterone + reduced_acceptor <=> 5alpha-dihydroprogesterone + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
|
BRENDA:
BS438426
|
|
|
|
progesterone + reduced_acceptor <=> pregnan-3,20-dione + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
|
BRENDA:
BS371125
|
|
|
|
progesterone + acceptor <=> 1,4-Pregnene-3,20_dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS258848
|
|
|
|
ATP + H2O + progesterone <=> ADP + phosphate + progesterone
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS376352
|
|
|
|
progesterone + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ + O2 <=> 9alpha-hydroxyprogesterone + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS418311
|
|
|
|
progesterone + NADPH + O2 <=> 17alpha-hydroxyprogesterone + NADP+ + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
1.14.14.25
cholesterol 24-hydroxylase
|
–
–
|
|
|
SABIO-RK:
7671
|
|
|
|
H+ + O2 + NADPH + progesterone <=> 6beta-Hydroxyprogesterone + H2O + NADP+
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
SABIO-RK:
13564
|
|
|
|
H+ + O2 + NADPH + progesterone <=> H2O + 16alpha-hydroxyprogesterone + NADP+
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
SABIO-RK:
13565
|
|